Saturday, February 18, 2006

Ramblings

Ramblings

So last night I was lying in bed reading Michel Foucault. (What, doesn’t everyone!?) To be specific, I was trying once again to get into The Archaeology of Knowledge, this was at least the third time I’ve started it. (The guy could not write a short sentence, or one that doesn’t contain multiple phrases set off by commas. Maybe it’s better in the original French, but I doubt it.) Now, Michel Foucault and stem cells are probably not put together very frequently, but the following bit really struck me:

In “sciences” like economics or biology, which are so controversial in character, so open to philosophical or ethical options, so exposed in certain cases to political manipulation, it is legitimate in the first instance to suppose that a certain thematic is capable of linking, and animating a group of discourses, like an organism with its own needs, its own internal force, and its own capacity for survival.
(35)
He goes on to point out the problems that he sees with this idea of linkage, but that is not what I am interested in talking about. It seems to me that he has really described embryonic stem cell research—and other biological research, especially biotechnical—and elucidated those issues which are not commonly foregrounded in the public eye. There’s a tendency to think of science as empirical and factual and to forget about the way in which it is a discourse itself. Facts and experiences are shaped by discourse. Foucault is writing in this book about the illusions of continuity in history; he sees history, especially history of thought or of ideas, as full of discontinuities, rifts, non-linearities. History is shaped in writing, and that writing is done by a person who exists within discourse as well. We as subjects cannot be free of language. The discourse of science is also shaped by speaking subjects who are shaped by language.

So what does all this mean? Well, it doesn’t mean that a protein is not a protein, or that a stem cell can’t be coaxed to differentiate predictably. The microcellular level is not so far fraught with the oddities and quirks (excuse me, quarks) of the subatomic realm (which have their own system and “rules”). Science with testable hypotheses can be done. But when the research is disseminated, when it becomes part of a body of knowledge, it is important to maintain awareness that the description of the event is not the event. In Foucaldian terms, our scientific knowledge is a discrete discursive body whose events are the formations of words, not the subject which the words attempt to describe. Because we are discursive beings, we are always at a linguistic remove—a discontinuity, if you will—from the biological happening. This seems to me to be a core element of the debate over the ethics of doing embryonic stem cell research; there is disagreement over the meaning of the discursive phrase “human life.”

Discourse also enters into stem cell research in a host of other ways—how grant applications are made, how information is presented to the public and to the government, how scientists speak with each other, and so on. Taking a view which allows us to think about the research results as being part of series with discontinuities rather than as an additional aggregation of cumulative, continuous knowledge, allows more openness for the unexpected and the innovative. It also is a reminder that ethics—which is essentially about how humans behave to each other—enters into all knowledge formation, and that learning can be a jerky process.

End of sermon. Thanks for reading.

Neural News

Neural News

I reported earlier in the week on a research team at Rice University that got better bone growth by using stem cells to form the scaffolding for the new tissue. Similar research with neural tissue is reported this week in the New Scientist. Researchers at the Burnham Institute in La Jolla, California have developed tiny (we’re talking millimeters here) scaffolds made out of the same material used to create dissolving surgical sutures. When the scaffolds are seeded with stem cells that produce neurons and them implant the scaffolds, the scaffold eventually dissolved but the stem cells remained. The researchers have seen spinal cord healing and improvement in mobility in rats who were implanted with the scaffolds. The rats did not regain complete mobility, but they regained significantly more than those rats who did not receive the stem cells. The stem cells in the scaffold are believed to help nurture the rat’s existing stem cells.

Note--New Scientists stories are generally subscription only—I was able to view this one, but I don’t know if it’s because it’s freely available or because the site had used cookies and knew I was a subscriber.

The Latest

The Latest

Hard research news continues to be thin. The American Association for the Advancement of Science has been meeting in St. Louis, and a couple of stories have come out of it analyzing the future of stem cell research in the Post-Hwang Days. An AP story on ABC News (American) says that for some scientists the effects could be research delays ranging from 6 months to three years. Other issues that the story mentioned were regulation; on the one hand, some scientists see a need for more transparent and public regulation of what’s going on, and on the other hand some of the existing regulations are too burdensome. Reuters, reporting on the same conference, says that researchers still see the work moving forward and holding excitement and potential. Both articles discussed human cloning; the AP story said that the silver lining to the Hwang cloud is that American researchers are not as far behind the rest of the world as it had appeared, and the Reuters story quotes a scientist as expecting that human cloning will be achieved in a few years. He said that it was a technical issue and the main difficulty is obtaining eggs.

And, speaking of Missouri (well, sort of, St, Louis….), Newsweek has a nice story about Sen. Jim Talent’s recent decision to withdraw support from the proposed bill that would criminalize embryonic stem cell research. The article also quotes extensively from the head of the Stowers Institute, whose wife is a bioethicist and ordained Methodist minister. I don’t think the story has much new to say to people who have been following stem cell research, including embryonic, for a while, but it’s well written and encapsulates some of the issues nicely.

As an aside—why are we as a culture so harsh on politicians who change their minds? Isn’t it a good thing to consider and reconsider issues and sometimes switch positions? If we allowed our elected representatives to consider the complexity of things and encouraged them to grow and learn, we would have a better government. I would be saying the same thing if Talent had switched the other direction provided that he had educated himself and consulted with people—we can’t ask for more than that. It is important to respect well-grounded ethical opinions even if one does not necessarily agree with them.